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Light and Electron Microscopic Studies of Tumors Induced by Small Plaque Variant of Chicken Embryo Lethal Orphan Virus¹

Animal Pathology Department, University of Rhode Island, Kingston, Rhode Island 02881

The light and electron microscopic appearances of four solid tumors induced in hamsters by the small-plaque variant of chicken embryo lethal orphan virus were studied. The tumors were composed of cells ranging from those that were undifferentiated to those with fibroblastic differentiation. Ultrastructurally, the neoplastic cells were characterized by nuclei with irregular contours; well-developed, rough endoplasmic reticulum; mitochondria; and abundant, free ribosomal clusters. One outstanding feature of these cells was the wrapping of the cisternal profiles of rough endoplasmic reticulum around the mitochondria. Although no adenovirus particles were discernible, virus-like particles resembling either the intracytoplasmic hamster type A particles or the Bernhard type were detected in two of the four tumors examined. The sera from two of the four tumor-bearing hamsters contained small-plaque virus-specific "T" antibodies, as demonstrated by indirect immunofluorescent techniques.

¹ Contribution 1436 of the Rhode Island Agricultural Experiment Station.

² Present address: Institute for Cancer Research, Fox Chase, Philadelphia, Pa. 19111.

Received 4/ 5/72. Accepted 6/15/72.