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Inhibition of Tumor Growth and Survival of Aged Mice Inoculated with Moloney Tumor Transplants and Treated with Endotoxin¹

Department of Zoology and Physiology, Rutgers University, Newark, New Jersey 07102

The pattern of tumor growth and mortality has been traced in CF 1/S female mice, ages 15 to 20 months, following inoculation with 3 x 10⁷ Moloney virus-induced sarcoma cells, propagated in 6-month-old CF1/S irradiated hosts. All the aged mice developed large tumors with widespread metastases, and 65% of these mice died before the end of the 60-day experimental period. Most younger mice tested (2 to 9 months old) rejected the tumor transplants and survived the 60 days. Administration of Salmonella enteritidis endotoxin i.m., in amounts greater than 0.01 µg, 3 times per week for 60 days, starting 24 hr after tumor inoculation, increased the mortality rate with increased numbers of deaths due to tumor growth. Amounts of 0.1 and 1.0 ng endotoxin markedly increased the survival rate as well as the rate of tumor regression. Since endotoxin has been shown to be a repressor of the immune system in high doses and a stimulator in a low doses, it is hypothesized that in aged mice ng amounts of endotoxin enhance immune responsiveness and thereby reduce death from tumors.

¹ This work was supported by NIH Biomedical Grant FR 7059 and Rutgers Research Council Grant 2085.

² Recipient of a Rutgers Research Council Fellowship during part of the tenure of which this work was done.

Received 4/28/72. Accepted 6/19/72.

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