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Anemia in Chickens with a Transplantable Lymphoid Tumor¹

Department of Veterinary Pathology and the Institute of Comparative Medicine, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30601

Chickens inoculated with a transplantable lymphoid tumor developed a progressive anemia that was classified morphologically as normochromic and normocytic. The bone marrow showed normal cellularity with no evidence of tumor metastasis, and immature erythrocytes were not detected in the peripheral blood. (Increased serum transferrin was correlated with a decline in both packed cell volume and hemoglobin concentration, as well as with time postinoculation). A positive relationship was observed between the degree of tumor growth, the reduction in both packed cell volume and hemoglobin, and the increase in serum transferrin. The direct Coombs' test on erythrocytes from tumor-bearing and control chickens was consistently negative. Certain similarities between the anemia is these chickens and that in many human cancer patients make the transplantable lymphoid tumor system a potentially useful model for comparative studies of the anemia associated with lymphoreticular neoplasia.

¹ Published as Manuscript 906. Supported in part by General Research Support Grant 10-03-RR208-014 (67) from the NIH.

² USPHS postdoctoral trainee in pathology.

Received 12/20/71. Accepted 6/21/72.