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Effect of Hepatoma Growth on the Utilization of Liver Glycogen in Rats¹

Department of Biological Chemistry, Sloan-Kettering Institute for Cancer Research, New York, New York 10021

Glycogen metabolism in the host livers of rats bearing a slow-growing hepatoma and in those with a rapidly growing hepatoma was investigated. Liver glycogen is depleted in fed or fasted rats bearing Novikoff hepatomas but not in rats with Morris 5123D hepatoma. In the latter, when fasted, the retention of liver glycogen is proportional to tumor size. Rates of synthesis of glycogen are equal in fasted normal rats and in those bearing Morris hepatoma 5123D.

¹ Supported by NIH Grant CA-08748 and Grant T431L from the American Cancer Society.

Received 3/21/72. Accepted 6/21/72.