This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Robl, M. G. Articles by Olson, C. Search for Related Content PubMed PubMed Citation Articles by Robl, M. G. Articles by Olson, C.

Intracranial Fibroblastic Neoplasms in the Hamster from Bovine Papilloma Virus¹

Department of Veterinary Science, University of Wisconsin, Madison, Wisconsin 53706

Intracranial fibroblastic neoplasms developed in 16 of 19 hamsters inoculated intracerebrally with bovine papilloma virus. The tumors presumably arose in the meninges and infiltrated the adjacent brain along the vascular channels. Tumor nodules that developed in the subcutis of the extremities, ears, and body were probably due to viremia following intracerebral inoculation. Fibroblasts of the cranial cavity and subcutis appeared to be more susceptible to the oncogenic action of bovine papilloma virus than fibroblasts elsewhere in the hamster.

¹ This research was supported in part by the College of Agriculture and Life Sciences, University of Wisconsin, Madison, Wis., and by NIH Grant CA 04627, Training Grant GM 817 General Medical Sciences, and Fellowship CA 34, 402-01.

² Present address: Department of Pathology, Kansas State University, Manhattan, Kansas 66502. To whom request for reprints should be addressed.

³ Present address: Industrial Biotest Laboratories, Northbrook, Ill. 60062.

⁴ Present address: Haskell Laboratory for Toxicology and Industrial Medicine, Newark, Del. 19711.

Received 9/ 7/71. Accepted 6/28/72.