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Presence of Antibody against Mouse Fetal Antigen in the Sera from C57BL/6 Mice Immunized with Rauscher Leukemia¹

Laboratory of Viral Oncology, Research Institute, Aichi Cancer Center, Nagoya 464, Japan

Presence of cross-reacting antibodies against embryonic cells and Rauscher leukemia cells was demonstrated in the sera collected from the C57BL/6 mice immunized with Rauscher leukemia cells, with the use of the indirect immunofluorescent test. Such cross-reacting antigenicity was also found in the SV40-transformed BLSV cells and AKR lymphoma cells. The antibody was completely absorbed with embryonic cells but not with adult spleen cells. Absorption tests showed that this antigen was different from Gross and Friend-Moloney-Rauscher antigens. However, the cross-reacting antibodies were not detectable in the sera from 13-month-old mice in which the natural antibody against Gross antigen was clearly demonstrated.

¹ This study was conducted under Contract NIH-69-96 within the Special Virus Program of the National Cancer Institute, NIH, USPHS, and was also supported by a grant-in-aid from the Ministry of Education of Japan.

Received 4/ 3/72. Accepted 7/11/72.