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Appearance of Abnormal Catalase Antigen and Concurrent Deletion of Normal Antigen in Leukocytes of Myelogenous Leukemia¹

Department of Pathology [E. T. N., Y. H.], and Department of Medicine [R. J.], University of Hawaii School of Medicine, Honolulu, Hawaii 96822

An immuoelectrophoretogram of catalase in peripheral blood leukocytes showed a distinctive pattern in patients with inflammatory leukocytosis in contrast to that in patients with myelogenous leukemia. An abnormal catalase-related antigen, , with anodic migration, coexisted with a normal cathodic or ß antigen in the peripheral blood leukocytes of patients with inflammatory diseases. Leukocytes of leukemic individuals, however, showed only the abnormal anodic antigen of catalase. This antigen underwent reversion to normal ß pattern during clinical remission. These and other observations suggest that transient configurational changes of leukocytic catalase molecules may occur under certain pathological states.

¹ Supported in part by NIH Grant CA-1030-06, USPHS.

Received 5/ 8/72. Accepted 7/13/72.