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Effects of Methotrexate and Cytosine Arabinoside on Polyamine Metabolism in a Mouse L1210 Leukemia

Baltimore Cancer Research Center, Laboratory of Pharmacology, National Cancer Institute, NIH, Baltimore, Maryland 21211

The effects of methotrexate and cytosine arabinoside on polyamine metabolism were studied in a rapidly proliferating leukemic tumor (L1210) in C57BL/6 x DBA/2 (hereafter called BDF₁) mice. Methotrexate, the most effective antileukemic drug in terms of increasing the median survival time also was the most effective, both in inhibiting the enzymes in the polyamine biosynthetic pathway and in decreasing the accumulation of polyamines by the tumor cells.

Received 5/30/72. Accepted 8/ 3/72.

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