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Receptor Sites for Concanavalin A on Human Peripheral Lymphocytes and on Lymphoblasts Grown in Long-Term Culture¹

Department of Microbiology, The University of Chicago, Chicago, Illinois 60637

Human lymphoblasts in long-term culture are specifically agglutinated by concentrations of concanavalin A that do not agglutinate normal human lymphocytes. The agglutination is inhibited by -D-methyl mannoside. Lymphoblast lines kept in long-term culture bound 2 to 3 times more concanavalin A per cell than did normal lymphocytes. Normal lymphocytes and lymphoblasts bound approximately equivalent amounts of concanavalin A per unit surface area.

¹ Supported in part by Grant AT(11-1) 2040 from the United States Atomic Energy Commission and by a grant from the Leukemia Research Foundation of Chicago.

² Present address: Division of Biology, The University of Texas at Dallas, Box 30365, Dallas, Texas 75230.

³ Trainee of the Medical Scientist Training Program at Chicago; supported by USPHS Grant 5T05-GM01939-05.

Received 5/ 2/72. Accepted 8/ 7/72.