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Alkaline Phosphatase Activity in Spontaneous and Induced Leukemias in SJL/J Mice¹

Departments of Chemical Immunology [N. H.-G.] and Biophysics [R. H.-G., H. N.], The Weizmann Institute of Science, Rehovoth, Israel

This study represents an analysis of the levels of alkaline phosphatase in the thymus, spleen, and liver, and in the mesenteric and peripheral lymph nodes of spontaneous or induced types of leukemia in SJL/J mice. Lymphatic leukemia, whether spontaneous or induced either by a leukemogenic virus or by 7,12-dimethylbenz(a)anthracene, caused a marked elevation in alkaline phosphatase activity in the tissues tested. This enzymatic activity increase is not thymus dependent but, rather, is a characteristic feature of murine lymphatic leukemia development, since it also occurred in thymectomized mice treated with 7,12-dimethylbenz(a)anthracene. In SJL/J mice that developed spontaneous reticulum cell neoplasms or myeloid leukemia (induced by irradiation), the levels of alkaline phosphatase activity were similar to normal levels.

¹ This work was supported by a generous grant from the Talisman Foundation, Inc., New York, N. Y.

Received 3/ 1/72. Accepted 8/15/72.

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