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HL-A and Lymphoid Tumors¹

Department of Laboratory Medicine [F. R. D., J. G. N. W., E. J. Y.], and the Department of Medicine [I. F., A. T.], University of Minnesota, Health Sciences Center, Minneapolis, Minnesota 55455

The incidence of HL-A antigens on peripheral lymphocytes of 154 patients with lymphoid tumors has been compared with that of 383 controls. With the use of the simple X² test and a 5% level of significance, seven different associations appear to be valid. However, when the p value is corrected by multiplying it by the number of factors investigated, only the association of HL-A12 with lymphocytic lymphomas and the 4c antigen with chronic lymphatic leukemia appear to be significant. The previously described increased incidence of W5 and 4c in Hodgkin's disease was not found in the population studied, nor was the HL-A2-12 phenotype found to be increased in acute lymphatic leukemia.

¹ This work was supported in part by American Cancer Society Institutional Research Grant IN-13L, Cardiovascular Program Project Grant HE-06314; National Cancer Institute Grants CA 08101, CA 05158, and CA 08832; and the Edmond J. Yunis Fund, University of Minnesota.

² Present address: Department of Clinical Pathology, Walter Reed General Hospital, Washington, D. C. 20012.

³ Present address: University of Dublin, School of Pathology, Dublin, Ireland.

⁴ To whom requests for reprints should be addressed, at Department of Laboratory Medicine, University of Minnesota, Mayo 198, Minneapolis, Minn. 55455.

Received 6/28/72. Accepted 8/17/72.