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Examination of the Carcinogenic and Cocarcinogenic Effects of Grenz Radiation¹

Department of Dermatology, University of California, School of Medicine, San Francisco, California 94122

The effects of the chemical carcinogen 7,12-dimethylbenz(a)anthracene on long-wavelength ionizing radiation (grenz ray)-induced carcinogenesis in the skin of hairless mice were examined. A carcinogenic amount of the grenz energy (20,500 R) was applied over a 12-month period. A single application of 7,12-dimethylbenz(a)anthracene 4 weeks before the initiation of the grenz ray exposures resulted in a significant acceleration of tumor growth and the incidence of deeply invading cancers. These findings simulate the influence of 7,12-dimethylbenz(a)anthracene ultraviolet-induced cancer formation, and confirm the additive effects of physical and chemical carcinogenic stimuli.

¹ This study was supported by grants from the Cancer Research Coordinating Committee, University of California, and the Committee on Research Evaluation and Allocation, University of California School of Medicine.

Received 7/20/72. Accepted 8/22/72.