This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Black, H. S. Articles by Douglas, D. R. Search for Related Content PubMed PubMed Citation Articles by Black, H. S. Articles by Douglas, D. R.

A Model System for the Evaluation of the Role of Cholesterol -Oxide in Ultraviolet Carcinogenesis¹

Departments of Dermatology [H. S. B., D. R. D.] and Biochemistry [H. S. B.], Baylor College of Medicine [H. S. B., D. R. D.], and Veterans Administration Hospital [H. S. B.], Houston, Texas 77025

Cholesterol -oxide (cholestan-5,6-epoxy-3ß-ol), known to be carcinogenic, was formed in the skin of hairless mice in response to UV radiation. The levels of compound formed were dose dependent. Three criteria, namely, comparable effects by both the primary incitant (ultraviolet light) and cholesterol -oxide, the same predisposing specificity, and a direct relationship between the ability of the primary incitant to form tumors and produce cholesterol -oxide, are suggested as the minimum required to establish a causal involvement of this compound in the etiology of UV carcinogenesis.

¹ Supported in part by the Morrison Trust of San Antonio, Texas; by the American Cancer Society; and by USPHS Research Grant CA13464-01 from the National Cancer Institute.

Received 6/15/72. Accepted 8/23/72.

This article has been cited by other articles:

				A. Hiratsuka, H. Yamane, S. Yamazaki, N. Ozawa, and T. Watabe Subunit Ya-specific Glutathione Peroxidase Activity toward Cholesterol 7-Hydroperoxides of Glutathione S-Transferases in Cytosols from Rat Liver and Skin J. Biol. Chem., February 21, 1997; 272(8): 4763 - 4769. [Abstract] [Full Text] [PDF]

				B. Ames Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases Science, September 23, 1983; 221(4617): 1256 - 1264. [Abstract] [PDF]

				J. T. Chan and H. S. Black Skin Carcinogenesis: Cholesterol-5 agr, 6 agr-Epoxide Hydrase Activity in Mouse Skin Irradiated with Ultraviolet Light Science, December 27, 1974; 186(4170): 1216 - 1217. [Abstract] [PDF]