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Differential Sensitivities of Human Melanoma Cells Grown in Vitro to Arabinosylcytosine¹

Departments of Surgery [S. C. B., M. M. R.], Developmental Therapeutics [D. H. W. H.], Clinical Pathology [B. D.], and Physics [R. M. H.], The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025

Four permanent strains of human malignant melanoma, derived from a single melanoma nodule in one patient, exhibited different survival responses to the S-phase-specific drug, arabinosylcytosine. In one strain, survival was reduced by a fraction equivalent to the proportion of cells in S phase. The other three stains were much more resistant to drug doses as high as 100 µg/ml treated for 1 hr; however, treatments of longer duration (up to 8 hr) did cause a reduction in the surviving fraction of one resistant strain tested. Different mechanisms of cell killing by arabinosylcytosine may be responsible for the differential responses observed in these four melanoma strains.

¹ Supported by Damon Runyon Memorial Cancer Fund 1059 and Contract PH 43-66-1156, Chemotherapy, National Cancer Institute, NIH, USPHS.

Received 6/ 1/72. Accepted 9/ 5/72.