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Early Enhancement of Plating Efficiency of Primary Mouse Embryo Cells by the Carcinogen Methylnitrosourea¹

Department of Pathology, Faculty of Medicine, The University of Western Ontario, London 72, Ontario, Canada

Primary mouse embryo cells, when placed on a regular pattern of replating, initially exhibit a cyclical pattern of proliferation. When such cells recover from the primary injury caused by the carcinogen methylnitrosourea, they acquire a markedly enhanced plating efficiency. This change is independent of the density of plating at which the cells were treated and is probably a true, induced, heritable change rather than a selection of a preexisting cell population. The change may be independent of changes in contact inhibition and may be one of the steps in the development of cancer in tissue culture.

¹ This work was supported by grants from the Medical Research Council of Canada.

Received 5/16/72. Accepted 9/11/72.