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Macrophage Production by the Bone Marrow of Tumor-bearing Mice¹

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213

Macrophage colony production in vitro by bone marrow cells was studied at intervals after the implant of a syngeneic mammary tumor into C3H female mice. Between 4 days and 2 weeks of progressive tumor growth, there was a significantly increased production of macrophage colonies from the tumor-bearing animals when compared with three types of controls. After 2 weeks, the colony production returned to normal. The implications of this relative to the response of the host to tumor are discussed.

¹ Supported by USPHS Grants CA-12102, CA-05949, and AI-08206.

² Present address: King's College Hospital, London, S.E. 5, England.

³ To whom reprint requests should be addressed, at University of Pittsburgh School of Medicine, Pittsburgh, Pa. 15213.

Received 6/27/72. Accepted 9/11/72.