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Graft-versus-Host Reactions and the Viral Induction of Mouse Lymphoma¹

Laboratory of Nuclear Medicine and Radiation Biology, Department of Medicine, School of Medicine, Center for the Health Sciences, University of California, Los Angeles, California 90024

The role of graft-versus-host (GVH) reactions in the development of lymphoma was studied in mice carrying murine leukemia virus and a genetic susceptibility to lymphoma development. GVH reactions were produced by inoculating parental spleen cells into CBA/H-T6T6 x AKR and SJL/J x AKR F₁ hybrids. The spleen cells were obtained from animals with and without previous exposure to murine leukemia virus. Thymic lymphomas were found to develop in high incidence in mice receiving spleen cells from virus-inoculated parental donors. The lymphomas were of host cell type. Manipulations designed to increase the intensity of the GVH reaction were shown to have no relationship to the development of lymphoma. It was also demonstrated that AKR cells had an impaired ability to produce GVH reactions and yet were highly lymphomagenic when they came from virus-inoculated donors. It was concluded that lymphomagenesis was directly related to the presence of virus in the spleen cells and not to the GVH reactions resulting from their inoculation.

¹ This investigation was supported by the University of California and by Contract AT(04-1)GEN-12 between the Atomic Energy Commission and the University of California.

Received 7/14/71. Accepted 10/11/71.