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Development of Neoplasia and Karyotype Analysis in Mice with Graft-versus-Host Reaction¹

Laboratory of Nuclear Medicine and Radiation Biology, Department of Medicine, School of Medicine, Center for the Health Sciences, University of California, Los Angeles, California 90024

When F₁ hybrid mice from a cross between strains CBA/H-T6T6 and SJL/J were given parental (SJL/J) spleen cells or cell-free preparations of parental spleen cells, reticulum cell sarcoma developed with increased incidence in both groups, compared with noninjected controls. The presence of graft-versus-host reactions in the cell-inoculated animals did not influence tumor development. When CBA/H-T6T6 x C3H F₁ hybrids were given C3H spleen cells, visible GVH reactions did not develop. The incidence of mammary tumors in the cell-inoculated females of this hybrid cross was significantly greater than that in controls not receiving cell inoculations.

Nonthymic lymphomas occurred in CBA/H-T6T6 x SJL/J hybrids and hepatomas developed in male CBA/H-T6T6 x C3H mice with equal incidence in all experimental groups.

Karyotype analysis of the reticulum cell neoplasms showed small numbers of donor cells and aneuploid (malignant) cells of host origin.

No evidence was found in the mouse strains tested in this study to support the hypothesis that the immunological disorder associated with a graft-versus-host reaction could eventuate in lymphoma.

¹ This investigation was supported by the University of California and by Contract AT(04-1) GEN-12 between the Atomic Energy Commission and the University of California.

Received 7/14/71. Accepted 10/11/71.