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Effect of DL-Glyceraldehyde on Mouse Neuroblastoma Cells in Culture¹

American Medical Center, Denver, and Department of Radiology, University of Colorado Medical Center, Denver, Colorado 80220

Neuroblastoma cells had a much higher rate of glycolysis than the Chinese hamster ovary K1 cells, although the former cell type had a longer doubling time (24 hr) than did the latter (12 hr). DL-Glyceraldehyde inhibited the glycolysis in both cell types to the same extent, but it reduced the growth of neuroblastoma cells more markedly than that of Chinese hamster ovary K1 cells. These data indicated that glycolysis may be more critical for the growth of neuroblastoma cells than for the Chinese hamster ovary K1. In our experimental conditions the higher glycolysis rate did not correlate with the faster growth rate of cells in culture.

¹ This work was supported in part by USPHS Research Grant NS09230 from the National Institute of Neurological Disease and Stroke. Part of this work was presented at the Annual Meeting of the American Association for Cancer Research, Chicago, Ill., 1971.

Received 6/14/71. Accepted 12/ 3/71.

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