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Liberation of a Mouse Uterus-specific Protein in the Serum during Uterine Carcinogenesis¹

Biomedical Centre, Laval University, Quebec 10, Quebec, Canada

An alkaline phosphatase that exhibited immunological specificity towards the mouse uterus was liberated in the serum during uterine carcinogenesis induced by dimethylbenzanthracene. A correlation was observed between the presence of neoplastic lesions and the appearance of this alkaline phosphatase in the serum. This specific protein, which was immunohistochemically localized in the endometrial epithelium of normal mice, was found in the tumor cells exhibiting keratinization. Diagnostic value of these findings has been implicated.

¹ This investigation was supported by a grant from the National Cancer Institute of Canada.

Received 7/14/71. Accepted 12/ 8/71.