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Coordinated Treatment of Childhood Rhabdomyosarcoma with Surgery, Radiotherapy, and Combination Chemotherapy¹

St. Jude Children's Research Hospital, Memphis, Tennessee 38101

Twenty children with rhabdomyosarcoma were treated in a coordinated program utilizing surgery, radiotherapy, and combination chemotherapy. Therapy was determined by the stage of disease at which treatment was initiated. Of the 20 patients, 15 developed complete regression of tumor; 4 patients developed partial response. Of the 9 patients who are alive, 7 have been tumor free for 2 to 39 months. Concurrent radiotherapy and prolonged, intensive, combination chemotherapy are well tolerated following surgery for rhabdomyosarcoma. The coordinated use of these modalities offers prospects of curing more children who have this tumor.

¹ Supported by Cancer Research Center Grant CA 08480 and Clincal Cancer Training Grant CA 08151 from the National Cancer Institute, and by ALSAC. Presented in part at the 62nd Annual Meeting of the American Association for Cancer Research, Chicago, Ill., April 8, 1971.

² To whom reprint requests should be addressed at St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tenn. 38101.

Received 9/30/71. Accepted 12/ 8/71.

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