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Transplacental Effect of Some Chemical Compounds on Organ Cultures of Embryonic Kidney Tissue

Institute of Experimental and Clinical Oncology of the Academy of Medical Sciences of U. S. S. R., Moscow, U. S. S. R.

Fragments of embryonic kidney were explanted in organ culture. The embryos were obtained from mice that, during the last third of their pregnancies, received the polycyclic hydrocarbons 7,12-dimethylbenz()anthracene (carcinogenic), benz()pyrene (carcinogenic), and their analogs anthracene (noncarcinogenic) and pyrene (noncarcinogenic); the carcinogenic cyclic amines, o-tolidine and 3,3'-dichlorobenzidine; the carcinogenic dimethylnitrosamine; and 2 aminoazo compounds, o-aminoazotoluene (carcinogenic) and its analog p-aminoazotoluene (noncarcinogenic). Viability and survival of the organ cultures after transplacental treatment with these substances was much higher than in the controls.

In contrast to the control cultures, the experimental cultures showed hyperplastic growth of epithelium that was nodular or diffuse or that formed solid, compact areas. In certain cases, papillary outgrowth and cystadenomas were observed, the latter appearing after treatment with aminoazo compounds. The incidence and intensity of epithelial growth proved to be greater after treatment with carcinogenic compounds as compared with noncarcinogenic analogs. In some cases, the changes were intensified with higher doses of the carcinogenic substances.

Received 2/16/71. Accepted 12/ 9/71.