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Polyadenylic-Polyuridylic Acid, and Adjunct to Surgery in the Treatment of Spontaneous Mammary Tumors in C3H/He Mice and Transplantable Melanoma in the Hamster¹

Departments of Immunology [F. L., A. S.], Surgery [J. L.], and Pathology[M. P.], Institut Gustave-Roussy, Villejuif (Val de Marne), France

In mice bearing spontaneous mammary adenocarcinoma, treatment with double-stranded polynucleotide complex poly A-poly U (a nontoxic stimulator of cell-mediated immunity) was a potent adjunct to surgery by reducing the rate of tumor growth and increasing significantly the mean survival time. In hamsters bearing a highly metastasizing transplantable melanoma, poly A-poly U reduced the appearance of early metastases by 50% as compared with untreated animals or animals treated by surgery alone.

¹ This work was supported by Centre National de la Recherche Scientifique, by Ligue International sur le Cancer, and by Grant Annil Dalface.

Received 10/25/71. Accepted 12/30/71.

This article has been cited by other articles:

				F Lacour, G Delage, and C Chianale Reduced incidence of spontaneous mammary tumors in C3H/He mice after treatment with polyadenylate-polyuridylate Science, January 24, 1975; 187(4173): 256 - 257. [Abstract] [PDF]