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Collateral Sensitivity of Resistant Lines of Mouse Leukemias L1210 and L5178Y¹

Division of Drug Resistance, Sloan-Kettering Institute for Cancer Research, New York, New York 10021

Resistant sublines with pronounced patterns of collateral sensitivity of the mouse leukemias L1210 and L5178Y were studied. The sensitivity to cytoxan, carbazilquinone, methotrexate, 6-mercaptopurine, and cytosine arabinoside was greatly increased. Median survival times of all lines, except L1210, were shorter when mice were X-irradiated. The growth potential in homologous mice and in hamsters was inversely related to the sensitivity to the chemotherapeutic agents. No uniform pattern in the distribution of chromosome numbers was associated with change in oncogenic potential.

¹ Supported in part by Grant CA 08748 from the National Cancer Institute, Grant T-107 from the American Cancer Society, and the Elsa U. Pardee Foundation. Part of the data was presented at the 62nd Annual Meeting of the American Association for Cancer Research at Chicago, Ill., April 8 to 10, 1971.

Received 10/21/71. Accepted 1/14/72.