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Renal Tumors and Other Lesions in Rats following a Single Intravenous Injection of Daunomycin¹

Pharmacology Division, Sloan-Kettering Institute for Cancer Research, New York, New York 10021

Groups of 20 young female Sprague-Dawley rats were given a single i.v. injection of either 20, 10, or 5 mg of daunomycin per kg or of 0.9% NaCl solution. Eighteen rats given the 20-mg dose died before 5 months; 2 were killed when debilitated at 51 days and were found to have chronic glomerulonephritis. Thirty-three rats from the groups given 5 or 10 mg were available for pathological study when the experiment was terminated after 1 year. Of these animals, 16 had 27 tumors. Kidney tumors were present in 6 rats, 2 had clear-cell carcinomas and, in 1 of this pair, an adenoma was also present. The remaining 4 rats had renal adenomas. The next most common tumor was in the genital tract, where 7 tumors were found in 5 rats. In the control rats, only 5 of the 20 animals had tumors; none of these involved the kidney or genitalia.

Nineteen of the treated rats in the 5- and 10-mg groups had chronic glomerulonephritis. This was associated with secondary hyperparathyroidism manifested by parathyroid hyperplasia, metastatic calcification, and hyperostotic bone disease.

¹ Aided by Grant CA 08748 from the National Cancer Institute USPHS. Presented in part at the 61st Annual Meeting of the American Association for Cancer Research, April 9 to 11, 1970.

Received 12/ 1/71. Accepted 2/11/72.

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