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Increased Activity of Polynucleotide Ligase from Rat Hepatoma Induced by N-2-Fluorenylacetamide¹

Drug Research Institute, Faculty of Pharmaceutical Science, Toyama University, Toyama [K. T., S. H., and N. H.], and First Department of Pathology, Nara Medical University, Kashihara, Nara, [N. I.], Japan

Polynucleotide ligase in both the soluble fraction and the nuclear extract, which catalyzes the covalent joining of 2 segments of an interrupted strand in a DNA duplex, was studied with normal rat liver and hepatoma induced by N-2-fluorenylacetamide. The activity of this enzyme in hepatoma was about 5 times greater in the soluble fraction and about 3 times greater in the nuclear fraction than in normal rat liver.

¹ This work was supported in part by the Scientific Research Fund of the Ministry of Education of Japan.

Received 9/ 7/71. Accepted 1/14/72.