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The Immunogenic Activity of Tumor Antigens Retained by The Reticuloendothelial Cells of Tumor-bearing Mice¹

Section of Experimental Radiotherapy, The University of Texas at Houston, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025

Killed tritium-labeled tumor cells were injected into the centers of s.c. tumor implants to determine the site of retention of effete material disseminated from growing tumors. The label was retained mainly in the livers of murine tumor hosts and was also found in the spleen, lungs, and large intestinal mucosa. The level of radioactivity decreased more rapidly in the liver than in other sites of retention.

Homogenates of livers from tumor hosts were found to be immunogenic. These homogenates were able to enhance the antitumor resistance of mice already primed with injections of radiation-killed tumor cells.

¹ This work was supported in part by USPHS Grants CA5047, CA6294, CA11138, and CA11430.

² Present address: Department of Radiation Medicine, Massachusetts General Hospital, Boston, Mass. 02114.

Received 10/29/71. Accepted 1/25/72.