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Herpesviruses in Tumors of Postspawning Rana pipiens¹

Department of Zoology, University of Minnesota, Minneapolis, Minnesota 55455

Herpesvirus particles were observed in renal tumors of Rana pipiens collected in rural Minnesota as long as 42 days after spawning. Tumor cytology differs from tumors of frogs collected during cold weather and suggests that the tumors are in transition from the virus particle-containing state to the inclusion-free state. The presence of viruses in tumors of frogs in breeding ponds may have epidemiological significance.

¹ This study was supported by Grant 990-B from the Damon Runyon Memorial Fund for Cancer Research, Inc., New York, N. Y.

Received 12/20/71. Accepted 2/26/72.

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