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The Response of Human Lymphoma Cells in Vitro to Bleomycin and 1,3-Bis(2-chloroethyl)-1-nitrosourea

Departments of Clinical Pathology [B. D.] and Surgery [J. K. N., S. C. B.], The University of Texas, M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas 77025

Asynchronous human lymphoma cells treated with 1,3-bis(2-chloroethyl)-1-nitrosourea exhibited a broad-shouldered, threshold-type survival curve similar to that obtained after X-irradiation, suggesting that damage must be accumulated before killing effect is expressed. The sensitivity of the lymphoma cells to bleomycin was expressed as a biphasic dose-response survival curve, suggesting the involvement of sensitive and less sensitive fractions of cells. A 1000-fold reduction in survival was observed following treatment with bleomycin for the duration of one cell cycle.

Received 1/18/72. Accepted 3/ 6/72.