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Differential Effects of Infection with Herpes Simplex Virus on the Chromosomes of Human Hematopoietic Cell Lines

Springville Laboratories, Roswell Park Memorial Institute, Springville, New York 14141 [C. C. H.], and Cell Laboratories, Roswell Park Memorial Institute, Buffalo, New York 14203 [J. M.]

The responses of nine human hematopoietic cell lines to infection with herpes simplex virus (HSV) ranged from a high incidence of chromosome aberrations, with rapid cell death and rapid increase in progeny virus, to no detectable effect on chromosomes and cell viability, with only limited HSV replication. Of four lines, two that were positive for Epstein-Barr virus (EBV) (derived from blood from two healthy individuals), and two that were negative (one from a patient with leukemia and one from a patient with infectious mononucleosis), all were very sensitive to HSV. Of five lines derived from Burkitt's lymphoma, four EBV-positive and one EBV-negative, all were relatively resistant to the virus. The degree of resistance varied among these five Burkitt lines, the EBV-free line being the least HSV resistant. Certain inherited characteristics of Burkitt cells may be responsible for the relative resistance.

Received 1/ 4/72. Accepted 3/ 7/72.