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Macromomycin, an Inhibitor of the Membrane Function of Tumor Cells

Institute of Microbial Chemistry, Shinagawa-ku, Tokyo, Japan

Macromomycin, a proteinaceous antitumor antibiotic, binds to the membrane of tumor cells and thereby preferentially inhibits DNA synthesis. The cytotoxicity could be abolished by removal of macromomycin from the binding locus by a brief treatment with trypsin.

Received 3/22/71. Accepted 2/29/72.