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Aldolase C in Cultured Mouse Glioblastoma Cells¹

Department of Molecular Oncology [S. S., K. S., T. S.], and Department of Cancer Cell Research [T. T., H, K.], The Institute of Medical Science, The University of Tokyo, P. O. Takanawa, Tokyo-108, Japan

Cells of a transplantable mouse glioblastoma were cultured in vitro. Aldolase C, which is specific to the brain and nerve among normal adult mammalian tissues and was retained in the transplanted tumor in vivo, was also detected in cells after cultivation for more than 200 days. The isozyme pattern of aldolase and the presence of glia cell-specific S-100 protein suggested that these cultured cells were glioblastoma cells. The aldolase isozyme specific to nerve tissues seems to be a useful marker for study of differentiation of glia cells.

¹ This work was supported by grants from Ministry of Education, Ministry of Health, Japan, and Seminar on Metabolic Regulation (Amino Acid and Protein).

Received 2/ 4/72. Accepted 3/ 8/72.