This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Amkraut, A. Articles by Solomon, G. F. Search for Related Content PubMed PubMed Citation Articles by Amkraut, A. Articles by Solomon, G. F.

Stress and Murine Sarcoma Virus (Moloney)-induced Tumors¹

Departments of Medical Microbiology [A. A.] and Psychiatry [G. F. S.], Stanford University School of Medicine, Stanford, California 94305, and Veterans Administration Hospital, Palo Alto, California 94304 [A. A., G. F. S.]

Stable stress-responsive models have been established in murine (Moloney) virus sarcomas, which lend themselves to further study of intervening immunological mechanisms. Maximum tumor size was increased in sex-segregated male BALB/c mice at 6 and 9 months of age and in females subjected to 3 days of electric shock stress following virus inoculation. Reduction in maximum tumor size was found in females shocked for 3 days prior to virus inoculation. Similarly, females that spontaneously showed fighting behavior developed smaller tumors. Possible endocrine and immunological factors contributing to these varied stress effects are discussed.

¹ This work was supported by the Veterans Administration and by USPHS Grant MH 15976.

Received 11/16/71. Accepted 3/23/72.

This article has been cited by other articles:

				M. E. Hyland A Functional Theory of Psychogenic Illness Theory Psychology, February 1, 1993; 3(1): 79 - 113. [Abstract]

				V Riley Psychoneuroendocrine influences on immunocompetence and neoplasia Science, June 5, 1981; 212(4499): 1100 - 1109. [Abstract] [PDF]

				L. Sklar and H Anisman Stress and coping factors influence tumor growth Science, August 3, 1979; 205(4405): 513 - 515. [Abstract] [PDF]