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Lymphatic Leukemia and Pulmonary Tumors in Female Swiss Mice Fed Bracken Fern (Pteris aquilina)¹

Department of Pathological Anatomy, College of Veterinary Medicine, University of Ankara, Ankara, Turkey [A. M. P., E. E.]; Scientific Divisions, Abbott Laboratories, North Chicago, Illinois 60064 [J. M. P.]; and Division of Clinical Oncology, University of Wisconsin Medical School, Madison, Wisconsin 53706 [G. T. B.]

Bracken fern (Pteris aquilina) mixed with a grain mixture (1:3 by weight) was fed to a group of 40 female 6-week-old Swiss mice intermittently every other week for a total experimental period of 60 weeks. Thirty-three mice survived 30 or more weeks and all developed lymphatic leukemia with multiple organ involvement. Additionally, 5 mice developed multiple pulmonary tumors. No urinary bladder or intestinal tumors, common in rats fed a similar bracken fern diet mixture, were found. No tumors were detected in 38 control mice that survived for 30 to 60 weeks while ingesting the grain mixture.

¹ Supported in part by Grant CA-08254 from the National Cancer Institute, USPHS, and by a grant from the Turkish Scientific and Technical Research Council.

² Career Development Awardee of the National Cancer Institute, USPHS (1-K4-CA-8245).

Received 2/18/72. Accepted 3/23/72.