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Survival of Hematopoietic and Leukemic Colony-forming Cells in Vivo following the Administration of Daunorubicin or Adriamycin¹

Division of Hematology and Oncology [A. R., T. V.], Mallinckrodt Department of Pediatrics, and Section of Cancer Biology [F. V.], Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110

In this study, the kinetics of the cytocidal action of daunorubicin and adriamycin on both leukemic and hematopoietic colony-forming units was investigated by the use of the spleen colony assay technique. The dose-survival curves were exponential in shape for both agents on the hematopoietic colony-forming units; however, for the leukemic colony-forming units, a broad shoulder region existed for both agents followed by an exponential decrease insurvival for increasing dose. Although more adriamycin than daunorubicin was required to give a comparable leukemic cell kill, adriamycin was much less toxic to the normal hematopoietic stem cells. Time-survival curves indicated that cytotoxic effects of both agents persisted in the host for 20 to 30 hr following administration.

¹ Supported by USPHS Grant CA-10435 from the National Cancer Institute and by the Leukemia Guild of St. Louis.

Received 1/21/72. Accepted 4/ 3/72.