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Increased Susceptibility of Cells from Cancer Patients with XY-Gonadal Dysgenesis to Simian Papovavirus 40 Transformation

Department of Pathology, The University of Texas Medical Branch, Galveston, Texas 77550 [D. M.], and Departments of Virology [J. M. B.] and Clinical Pathology [J. M. T., A. C.], The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025

Genetically susceptible cells in culture can be transformed by oncogenic viruses. Quantitative assay methods have been developed for estimating the frequency of transformation. In an attempt to estimate the susceptibility to transformation of cells from cancer patients with XY-gonadal dysgenesis, fibroblasts from two such patients were infected with simian papovavirus 40, and transformation frequency was determined. Results of the quantitative assay indicate that the cells from these two patients were highly susceptible to transformation. It therefore appears that XY-gonadal dysgenesis resembles in this respect the group of disorders including Fanconi's anemia, Down's syndrome, and Klinefelter's syndrome, in which there is increased transformation frequency of the individual's cells after infection with simian papovavirus 40 in vitro.

Received 12/ 3/71. Accepted 3/27/72.