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Alteration of the Specificity of Antitumor Antisera by the Use of Passively Administered Antibody

Section of Immunology and Cell Biology, NIH, National Cancer Institute, Baltimore Cancer Research Center, Baltimore, Maryland 21211

Antispleen antibody was produced in burros by immunization with C57BL/6 spleen lymphocytes. The effect of passive administration of this antiserum in inhibiting antibody production to antigenic determinants common to both C57BL/6 lymphocytes and EL4 tumor cells was studied. Simultaneous immunization with EL4 cells and antispleen antibody resulted in specific alteration of anti-EL4 activity so that cross-reactivity to splenic lymphocytes was diminished. These results demonstrate the potential usefulness of passive antibody administration in altering host immunological responsiveness to antigenic determinants on tumor cells.

Received 2/16/72. Accepted 4/ 3/72.