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A Study of Multinucleated Tumor Cells Demonstrating the Effect of Transplant Duration on Serum Changes in Cancer-bearing Hamsters¹

Department of Zoology, University of Vermont, Burlington, Vermont 05401

A cancer-induced change occurs in the serum of golden hamsters bearing transplantable cheek pouch tumors. The appearance of this change is a function of time after transplantation and the number of tumor cells injected into the animals. The serum change is caused by 1.5 x 10⁶ tumor cells within 24 hr after transplantation. Removal of the cheek pouch by surgical excision caused the serum change to disappear within 6 to 8 days. The criterion used to detect these changes was the ability of the serum to reduce the number of hamster ascites multinucleated cells in vitro. The serum change appears to be associated with the seromucoid fraction of cancer serum.

¹ Supported in part by a grant from the Ortho Research Foundation, Raritan, N. J.

² This paper was submitted in 1970 to the University of Vermont in partial fulfillment of the requirements for the degree of Master of Science.

Received 12/ 2/71. Accepted 4/14/72.