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Use of Bacillus Calmette-Guérin as Adjuvant in Human Cell Vaccines¹

Department of Medicine B, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14203

Repeated intradermal vaccination with mixtures of cultured cells and living Bacillus Calmette-Guérin organisms induced delayed hypersensitivity to antigens of the target cells in three-fourths of the patients studied. This was associated with relatively little antibody production. The specific sensitization was accompanied by persistent general increase of cellular immune reactivity, in most cases. Morbidity from these vaccinations was usually negligible, and there were no serious complications. This technique of immunization may prove useful for active immunotherapy of human neoplastic disease.

¹ This work was supported in part by USPHS Grant CA-12243.

Received 1/21/72. Accepted 4/14/72.