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Aspartyl Transfer RNA Profiles in Normal and Cancer Cells¹

The Department of Biochemistry, The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025 [W. T. B., W. T., A. C. G.], and The Department of Microbiology, College of Medicine, M. S. Hershey Medical Center of The Pennsylvania State University, Hershey, Pennsylvania 17033 [R. D., F. R.]

Aspartyl-tRNA elution profiles were obtained from normal rat and hamster livers, Novikoff ascites hepatoma cells, and two different virus-induced (SV40) hamster tumors. A characteristic two-peak pattern was observed consistently in studies of the normal livers or the ascites tumor cells. However, the virus-induced tumors exhibited a third, late eluting peak in the reverse-phase chromatography system.

¹ Supported by grants from The American Cancer Society, Inc., and The Robert A. Welch Foundation and by National Cancer Insitute Grant CA-11647.

² American Cancer Society Professor of Biochemistry.

Received 3/17/72. Accepted 5/ 1/72.