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Variation of Hepatic Malic Enzyme Capacity with Hepatoma Susceptibility in Mice of Different Genotypes¹

The Institute for Cancer Research, Fox Chase, Philadelphia, Pennsylvania 19111, and McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, Wisconsin 53706

The incidence of spontaneous hepatoma in yellow and black male mice of the inbred YS/Wf and VY/Wf strains was determined. Among YS males, tumors were found in 11% of the yellow (A^y/a) and in 3% of the black (a/a) animals. Within the VY strain, tumors occurred in 24% of the yellow (A^y/a) and in 13% of the black (a/a) males.

Among the four strain-genotype categories, the incidence at 12 to 16 months of age paralleled the catalytic capacity of hepatic malic enzyme at 8 and 14 weeks of age.

¹ The research described in this report involved animals maintained in animal care facilities fully accredited by the American Association for Accrediation of Laboratory Animal Care.

² Supported by Grants CA-06927 and RR-05539 from the NIH and by an appropriation from the Commonwealth of Pennsylvania.

³ Supported by grants from the National Cancer Institute (CA-07175) and the American Cancer Society (E-588).

Received 11/ 1/71. Accepted 5/24/72.

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