This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hardesty, C. T. Articles by Mead, J. A. R. Search for Related Content PubMed PubMed Citation Articles by Hardesty, C. T. Articles by Mead, J. A. R.

The Effect of Route of Administration on the Distribution of Ellipticine in Mice¹

Microbiological Associates, Inc. [C. T. H., N. A. C.], and National Cancer Institute, NIH [J. A. R. M.], Bethesda, Maryland 20014

A single dose of ellipticine administered p.o. or i.p. is markedly active against i.p. mouse leukemia L1210. The physiological distribution of ellipticine was studied in mice after this agent had been administered, in solution and as a suspension, p.o. and i.p. The presence of ellipticine in tissues was determined by a sensitive photometric method, with a lower limit of 0.5 µg of drug per g of tissue. The drug is widely distributed, concentrations in tissues being dependent on route of administration. The highest and lowest tissue levels of ellipticine are observed after its administration i.p. in solution and suspension, respectively. The major portion of excreted ellipticine is present in the feces; only trace amounts are present in urine.

¹ This investigation was supported in part by Contract PH43-68-1283 with Drug Research and Development, Chemotherapy, National Cancer Institute, NIH, Bethesda, Md. 20014.

Received 1/18/72. Accepted 5/25/72.