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Studies on the Inhibition by Ethionine of Aminoazo Dye Carcinogenesis in Rat Liver

Institut de Recherches Scientifiques sur le Cancer, 16, Avenue Vaillant-Couturier, 94-Villejuif, France

In rats on a basal diet, the long-term feeding of 0.1% DL-ethionine did not induce hepatomas, and it delayed the process of tumorigenesis in rats fed a diet of 0.06% 4-dimethylaminoazobenzene (DAB). Both incidence and growth of DAB-induced hepatomas were significantly inhibited. In ethionine-fed rats, the binding of DAB metabolites to liver DNA and protein was markedly decreased; reduced binding to both molecular species occurred early, to an approximately equal extent. Neither the DAB-induced increase of thymidine-³H incorporation nor the rate of protein synthesis was affected by ethionine.

¹ To whom correspondence related to this paper should be addressed at the Institut de Recherches Scientifiques sur le Cancer, 16, Avenue Vaillant-Couturier, 94-Villejuif, France.

Received 10/ 8/71. Accepted 5/19/72.