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An in Vivo Evaluation of the Immunosuppressive Action of Bleomycin¹

Department of Comparative Medicine, The Milton S. Hershey Medical Center, College of Medicine, Hershey, Pennsylvania 17033

The new antineoplastic antibiotic, bleomycin, was evaluated in a non-H-2 allograft system (DBA/2 BALB/c) for immunosuppressive action. At high doses, the drug significantly altered graft rejection times. The high mortality and severe debility at these doses, however, suggest that the prolonged allograft survival times were not mediated by specific immunosuppression.

¹ This study was aided in part by Grant IC-46 from The American Cancer Society.

Received 7/12/71. Accepted 6/ 7/72.