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Early Lesions in Cats Inoculated with Feline Leukemia Virus¹

Departments of Veterinary Pathobiology and Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210

Morphological alterations in the thymus, lymph nodes, and bone marrow were determined at 2-week intervals in 21 cats inoculated at birth with feline leukemia virus and in 19 age-matched control cats. Severe thymic atrophy was detected at 5 weeks of age. Thymic atrophy was due primarily to extensive depletion of cortical thymocytes while the medullary components of many thymic lobules persisted. Apparent stages in the development of lymphosarcoma from atrophic thymuses were detected in cats examined between 11 and 19 weeks of age. Lymphosarcoma was detected as early as 9 weeks in some cats, by examination of bone marrow biopsies.

¹ Supported by NIH Contract PH-43-65-1001 from the Special Virus Cancer Program, and by NIH Grants RR-05463 and GM-1052.

Received 7/28/72. Accepted 10/11/72.

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