This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Zain, B. S. Articles by Imrie, R. C. Search for Related Content PubMed PubMed Citation Articles by Zain, B. S. Articles by Imrie, R. C.

Effect of 5-Azacytidine on Phytohemagglutinin-stimulated Horse Lymphocytes and Cultured Mouse L929 Cells

Institute of Biochemistry, University of Glasgow, Glasgow G12 8QQ, Scotland

The effect of 5-azacytidine on the metabolism of phytohemagglutinin-stimulated horse lymphocytes and cultured mouse L929 cells has been investigated. No significant differences have been found between the two cell types. The effects of 5-azacytidine become irreversible after 1 hr of treatment and, at this time, protein synthesis is dramatically inhibited. Subsequently, inhibition of RNA and DNA synthesis occurs.

¹ Holder of a British Commonwealth Scholarship. Present address: School of Internal Medicine, Yale University, New Haven, Conn. 06510.

² Present address: Beecham Research Laboratories, Betchworth, Surrey, England.

Received 6/ 8/72. Accepted 10/ 3/72.