This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Buzzi, S. Articles by Maistrello, I. Search for Related Content PubMed PubMed Citation Articles by Buzzi, S. Articles by Maistrello, I.

Inhibition of Growth of Ehrlich Tumors in Swiss Mice by Diphtheria Toxin

Pharmacological Research Laboratories, Farmila S, p. A., Settimo Milanese 20019 [I. M.], and A. V. I. S. Blood Bank, Ravenna 48100, Italy [S. B.]

The effect of diphtheria toxin on tumor cells was studied in mice with transplanted Ehrlich ascites or solid tumor. For ascites tumor, the results were assessed on the bases of the trend in body weight, the incidence of ascites on the 13th day after transplantation, and the survival time. For solid tumor, the results were assessed on the basis of the weights of the dissected tumors. The results obtained demonstrate inhibition of both ascites and solid tumors. Inhibition of ascites tumor was dose dependent but the higher doses were toxic. The treatment was most effective after i.p. administration and weakest after s.c. administration. The i.p. route permitted a highly significant increase in survival time. The effectiveness of s.c. administration was improved when a given amount of diphtheria toxin was divided over several administrations, one per day, rather than administered in a single dose. Inhibition of solid tumor by i.p., i.m., and s.c. treatment was approximately 70%. Some possible explanations for the difference in sensitivity between normal and cancer cells are discussed.

Received 3/ 7/73. Accepted 6/11/73.

This article has been cited by other articles:

				S A McCarthy, M L Samuels, C A Pritchard, J A Abraham, and M McMahon Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes. Genes & Dev., August 15, 1995; 9(16): 1953 - 1964. [Abstract] [PDF]