This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Andersen, R. A. Search for Related Content PubMed PubMed Citation Articles by Andersen, R. A.

Carcinogenicity of Phenols, Alkylating Agents, Urethan, and a Cigarette-Smoke Fraction in Nicotiana Seedlings¹

Department of Agronomy, United States Department of Agriculture, Agricultural Research Service, University of Kentucky, Lexington, Kentucky 40506

Aqueous solutions of the phenols pyrogallol, resorcinol, and 3-hydroxyanthranilic acid, several alkylating agents, urethan, and a water-soluble extract of cigarette-smoke condensate induced tumors during early seedling development in one or both of two higher plants. The seeds of tumor-prone interspecific hybrids of the diploid Nicotiana glauca x Nicotiana langsdorffii and the tetraploid Nicotiana suaveolens x N. langsdorffii were soaked in aqueous solutions of these agents for 24 to 48 hr, and tumors were scored on germinated seedlings 20 days later. The carcinogenic activity of several of the active compounds or structurally related compounds has already been demonstrated in animal bioassay systems. The parallel activity in Nicotiana hybrids suggests a mechanism of oncogenic action common to certain plant and animal tissues.

¹ This investigation is a cooperative project between the Agricultural Research Service, the United States Department of Agriculture, and the Kentucky Agricultural Experiment Station. It is published as Journal Article 73-3-54.

Received 4/30/73. Accepted 6/28/73.