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Genetic Factors in Chronic Remittent Friend Disease¹

Department of Pathology, University of Oregon Medical School, Portland, Oregon 97201 [P. J. D.], and Stanford Research Institute, Menlo Park, California 94025 [A. H. F.]

C57BL/6 and C57BL/Ks mice possess the alleles H-2^b and H-2^d, respectively. A study of Friend disease in C57BL/6 x DBA/2 F₁ and C57BL/Ks x DBA/2 F₁ mice showed that remittent disease occurred in the former hybrids and progressive disease in the latter. Since both hybrids have the same Fv-1 and Fv-2 genotypes the change in the character of the disease was ascribed to differences in the Rgv-1 gene located near the H-2 locus. The lymphatic leukemia-inducing virus that acts as helper for Friend virus was shown to replicate better in C57BL/Ks than in C57BL/6 mice, suggesting that Rgv-1 gene may regulate the occurrence of remissions through its action on the helper virus.

¹ This work was supported in part by Grant DRF-1123 from the Damon Runyon Memorial Fund for Cancer Research, a grant from the American Cancer Society, Oregon Division, Inc., and by USPHS Grant CA-07868 from the National Cancer Institute.

Received 5/10/73. Accepted 6/28/73.