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Paramagnetic Changes during Development of a Transplanted AKR/J Leukemia in Mice as Measured by Electron Spin Resonance¹

Radiation Biology and Biophysics Laboratory of the Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226

Paramagnetic changes occurring during tumor development were studied in the mouse AKR leukemia (transplanted) model system using electron spin resonance. Paramagnetic changes were found only in blood and in organs directly involved by the leukemic cells. The change in blood consisted of an increase in a paramagnetic transition element complex, and occurred prior to the tissue changes. In the liver, both free radicals and normally occurring transition elements decreased when the liver became extensively infiltrated by the leukemic cells. Similar results were found in the spleen, except that in the spleen there also was an increase of a paramagnetic transition element or elements, with an apparent g factor near g = 2.003, plus the development of additional hyperfine structure in proportion to tumor involvement. An early rise in free radicals, which has been reported as characteristic of tumor development, was not observed in these studies.

¹ These studies were supported by research funds from the John Hartford Foundation and Oshkosh Area United Fund.

Received 2/15/73. Accepted 7/11/73.

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